Abstract: Objective: To evaluate the effect of implementing hospital-community -family integrated care in patients with depression. Methods: The authors selected 54 depression patients, and then implemented hospital-community-family integration service to follow up the patients. WHO Quality of Life-Abbreviated Version (WHOQOL-BREF) and Suicidal Ideation of Self rating Scale (SIOSS) were used to evaluate the effects before and after 6-month intervention, respectively.Results: After 6-month intervention, the scores of three dimensions in SIOSS, named despair, sleep and optimistic factors were better than pre-intervention (P<0.01). The scores of physiological and psychological dimensions, and the general level of WHOQOL-BREF were higher than pre-intervention (P<0.01). Conclusion: Hospital-community-family integrated care model could effectively improve the quality of life in patients with depression, reduce the risk of suicide and ensure their safety.