Abstract: Objective: To establish and evaluate a whole course double-tutor clinical practice model based on primary holistic nursing. Methods: By convenience sampling method, 182 undergraduate nursing students in 2014 were recruited as experimental group, and received the double-tutor clinical practice model based on primary holistic nursing. One hundred and sixty-five undergraduate nursing students in 2013 were recruited as control group, and adopted the traditional model.Results: The students' comprehensive examination score, professional identity and attitudes toward the clinical practice models in the experimental group were significantly better than those in the control group (P<0.05). The patient satisfaction score with nursing students in the experimental group were significantly higher than those in the control group (P<0.05).Conclusion: The whole course double-tutor clinical practice model based on primary holistic nursing was consistent with the current objectives of higher nursing education, and is worth of further popularization.