Abstract: Objective: To study the influence of Cancer-Related Fatigue on life quality of nasopharyngeal carcinoma patients undergoing radiotherapy. Methods: A total of 84 nasopharyngeal carcinoma patients undergoing radiotherapy were investigated using Cancer Fatigue Scale (CFS), and EORTC QLQ-C30. Results: the total score of CFS was (25.43±7.38). Among all the subscales, the scores of emotional fatigue were higher, which means the emotional fatigue was more severe. The score of overall health status was (53.57±18.26). Multiple stepwise regression analysis indicated that among different dimensions of fatigue only emotional fatigue was put into regression equation. The more serious of emotional fatigue, the worse of patients' overall health status. Conclusion: Patients of nasopharyngeal carcinoma undergoing radiotherapy may have Cancer-Related Fatigue which seriously affects their quality of life. Health care professionals should pay attention to this problem and take interventions to relieve fatigue.