Abstract: Objective: To explore the effect of Quality Control Circle (QCC) activities on reducing the blocking rate of power peripherally inserted central catheter (PICC). Methods: Totally 278 breast cancer patients from May to June 2014 got routine catheter care. From July, 2014, the authors organized QCC activities, including blocking causes analysis, goal setting,formulating and implementing countermeasures. The other 251 patients with power PICC from November to December received QCC management method. The blocking rates of PICC before and after the QCC activities were collected and analyzed. Results:The blocking rate dropped from 28.4% to 12.0% after QCC management (P<0.05). Conclusion: QCC activities could reduce the blocking rate of Power PICC.