Abstract: Objective: To explore the effects of early postoperative activity plan in early postoperative ambulation of patients with endoscopic common bile duct surgery. Methods: Totally 185 cases of patients after laparoscopic common bile duct operation were selected in this study. They were divided into two groups, the observational group (93 cases) and the control group (92 cases). Patients in the control group received usual care, while patients in observational group got strictly planned care based on the early postoperative activity plan. Time for the first ambulation, postoperative exhausts time,hospitalization days, incidence of DVT and pulmonary infection, and patients' satisfaction were collected and analyzed. Results: Time for the first ambulation in the study group was shorter than that in the control group (P<0.05). Postoperative exhausts time, hospitalization days, incidence of DVT and pulmonary infection, and patients' satisfaction were better in the study group than those in the control group (P<0.05).The rates of pain complaints, worry about wound dehiscence, unexpected extubation, and mental problems were less than control group (P<0.05). Conclusion: Early postoperative activity plan can encourage early postoperative ambulation in patients with endoscopic CBD surgery, and then promote postoperative exhaust, shorten hospital stay, reduce postoperative complications, and improve patients' satisfaction.