Abstract: Objective: To explore the fatigue status of patients with Inflammatory Bowel Disease (IBD) and its influencing factors. Methods: A total of 150 patients with IBD from a tertiary A-level general hospital in Beijing were investigated with Multidimensional Fatigue Scale (MFS), Zung Self-Rating Anxiety scale (SAS), Zung Self-Rating Depression Scale (SDS) and Pittsburgh Sleep Quality Index (PSQI). The influencing factors of fatigue among patients with IBD were analyzed. Results: The score of total fatigue was (60.21±13.63). Depression, payment schemes and sleep quality index were the main influential factors of IBD patients' fatigue. Conclusion: The fatigue of patients with IBD was at a high level. Multiple measures should be taken,including improving the sleep quality, providing psychological care, decreasing unnecessary medical costs to improve the fatigue status of patients.