Abstract: Objective: To investigate the effect of two methods of using ventilator heated humidifier humidification device combined with Venturi oxygen and using T tube device of humidified oxygen among mechanical ventilation weaning patients.Methods: According to the random number table method, 100 eligible patients were randomly divided into the observation group and the control group with 50 cases in each group. The observation group used the method of ventilator heated humidifier humidification combined with Venturi apparatus oxygen, and the control group was treated with T tube device of humidified oxygen method.Results: Oxygen saturation in observation group was (97.38±1.56)% after 8h of mechanical ventilation weaning, while that in control group was (92.5±1.88)%, and the difference was statistically significant (P<0.05). The sputum viscosity in the observation group(I 60%, II 32%, III 8%) was better than that in the control group (I 24%, II 26%, III 50%) .There was a significant difference in the effect of airway humidification, irritating cough, and airway mucosal hemorrhage between the two groups (P<0.05). Conclusion:The method of ventilator heated humidifier humidification device combined with Venturi oxygen could support the oxygenation state effectively, expel sputum easily, and reduce the occurrence of complications and adverse reaction of artificial airway. Its method is better than T tube device of humidified oxygen method.