Abstract: Objective: To revise and evaluate the validity and reliability of the Chinese version of Caregiver Reaction Assessment (CRA) for the primary family caregivers of hospitalized patients with cancer. Methods Totally 722 primary family caregivers of hospitalized patients with cancer were investigated with translation of CRA. The reliability and validity were examined by exploratory factor analysis (EFA), confirmatory factor analysis (CFA), Cronbach's α coefficient, and the Guttman split half coefficient, then the scale was revised and evaluated. Results: Using EFA, Chinese version CRA consisted of 4 factors explaining 55.49% of the total variance. The Cronbach's α of the total scale and subscales were 0.760~0.881, and Guttman split half coefficients of the total scale and subscales were 0.693~0.879. No significant floor and ceiling effects were detected.Conclusion: The Chinese version CRA has good validity, reliability and precision. It is an useful instrument to evaluate burden of primary family caregivers of hospitalized patients with cancer.