Abstract: Objective: To establish a scientific, standardized and practical work division of the clinical nurses based on nurses grading management. Methods: The data analysis method and field research method are used to preliminarily define the work division contents of the clinical nurses of different grades in the inpatient area; then the Delphi expert inquiry method was implemented to establish the work division of the clinical nurses of different grades. Results: In the expert inquiry, the effective response rate of the questionnaire in two rounds was 79.1% and 95.0%, with authority coefficient of 0.868 and 0.875 and coordination coefficient of 0.209 and 0.271 (P<0.01), respectively. It also established a 52-item work division system, including 6 items for N0-grade nurse, 6 items for N1-grade nurse, 10 items for N2-grade nurse, 10 items for N3-grade nurse, 10 items for N4-grade nurse and 10 items for N5-grade nurse. Conclusion: The work division establishment of the clinical nurses of different grades in the inpatient area was scientific, reliable and practical, and it provided a clear and specific guidance to the clinical nurses' work in inpatient area.