Abstract: Objective: To explore the turnover intention and work-family conflict among nurses in pediatric outpatient department and the effect of work-family conflict on turnover intention, and to provide references to prevent nurses' turnover.Methods: A total of 243 staff nurses in pediatric outpatient department from 13 tertiary Grade A general hospitals in Shandong province were investigated with Work-Family Conflict Scale and Turnover Intention Questionnaire. Results: The mean score of work-family conflict was (2.31±0.58) and 47.7% of nurses had turnover intention. Logistic regression indicated that age, overtime work, base on pressure conflict and base on behavior conflict were the influencing factors of turnover invention. Conclusion:Turnover intention among nurses in pediatric outpatient department is high and it is influenced by work family conflict. Hospital managers should take effective measures to reduce job pressure and work family conflict to decrease turnover rate among nurses in pediatric outpatient department.