Abstract: Objective: To explore a new management method of expensive leftover medications in cancer targeted therapy.Methods: We set up a series of standardized management measures related to preservation and use of expensive leftover medications in cancer targeted therapy, and then implemented the management system in our department. Results: In these two years, the management of expensive leftover medications for targeted therapy in our department met the requirements of hospital administration. The leftover medications had always been administered to the cancer patients timely and accurately to ensure the medication efficiency. Meanwhile, it also decreased medical expense for patients. No medication error occurred. Conclusion: The new management method could improve patient's satisfaction and reflect the essence of patient-centered care.