Abstract: Objective: To analyze the work status, clinical application and management of specialized nurse, and to provide recommendations and strategies for cultivation and management of specialized nurse. Methods: A retrospective survey was conducted to investigate the qualified specialized nurse trained by Anhui training base for specialized nurses from 2006 to 2012 by self and peer- assessment. Results: Primary professional title accounted for 49.27% of the specialized nurses; 92.58% of them were distributed mainly in Class III Grade A hospital and Class II Grade A hospitals; the amount of nurses trained in each institution had a large difference; 82% of them were mainly engaged in general clinical nursing work, and played a relatively weak role in senior clinical practice, quality management and research. Conclusion: The status quo is still insufficient resulting from low selection criteria, lacking of long-term planning, lacking of professional management, emphasizing the training and overlooking the employing. And they are still a young team. The role of senior clinical practice is still not fully developed.