Abstract: Objective: To systematically evaluate the effects of hydrocolloid dressing in preventing Peripherally Inserted Central Catheter-related mechanical phlebitis. Methods: The authors searched the Cochrane Database of Systematic Reviews,JBI Database of Systematic Review, EMBase, PubMed, CBMdisc, Wanfang Data and CNKI to collect randomized controlled trials (RCTs) and quasi-Randomized Controlled Trials (q-RCTs) which studied the effects of hydrocolloid dressing in preventing Peripherally Inserted Central Catheter-related mechanical phlebitis. The quality of RCTs and q-RCT were critically appraised and data were extracted by 2 reviewers independently. Meta-analyses were conducted for the eligible RCTs. Results: 9 RCTs were included. The meta-analysis had showed that hydrocolloid dressing could decrease the rate of Peripherally Inserted Central Catheter-related mechanical phlebitis significantly. Conclusion: Hydrocolloid dressing was effective to prevent Peripherally Inserted Central Catheter-related mechanical phlebitis.