Abstract: Objective: To explore the effect of caregiver synchronous education on quality of life(QOL) among nasopharyngeal carcinoma (NPC) patients treated with radiotherapy. Methods: NPC patients treated with radiotherapy in two different head and neck departments in a tertiary cancer hospital from November to December, 2014 were recruited with 34 patients in one department as the experimental group and 33 patients in another department as the control group. The patients in the control group received conventional education and the patients in the experimental group received patients and caregivers' synchronous education. Patients' QOL was measured by EORTC QLQ-C30 before the intervention, 6 months and 12 months after discharge to compare the effect of the intervention in two groups. Results: Repeated measures analysis of variance showed that the main intervention effect, the main time effect and the interaction between intervention and time on global health status, emotional function, social function and fatigue had statistical significance (P<0.05) in two groups. Conclusion: Caregiver synchronous education could improve the QOL of NPC patients treated with radiotherapy.