Abstract: Objective: To investigate sleep quality and impact factors in patients with inflammatory bowel disease(IBD). Methods: Totally 120 patients with inflammatory bowel disease were investigated. Participants completed a survey on socio-demographic characteristics, the Pittsburgh Quality Sleep Index (PSQI) and the Disease Activity Index (DAI).Result:The incidence of sleep disorders in patients with inflammatory bowel disease was 55.8% (Ulcerative Colitis: 47.6%;Crohn's Disease: 64.9%). The PSQI total score was 8.07±2.91, which was significantly higher than normal values (P<0.05).In decreasing order, the score of each domain of the PSQI was sleep latency (1.62±0.74), subjective sleep quality (1.54±0.66),sleep duration (1.16±0.71), sleep disturbance (1.10±0.42), sleep efficacy (0.89±0.63), the use of sleeping medications(0.17±0.37), the score of daytime dysfunction was 1.59±0.76. Stepwise regression analysis showed that active disease,unemployed, female and using hormonal drugs were related to sleep quality. Conclusion:Patients with IBD have poor sleep quality, which associate with DAI, the situation of work or study, gender and medication. Sleep quality evaluation should be considered as a part of inflammatory bowel disease management program.