氯己定全身洗浴对预防ICU患者导尿管相关性尿路感染的Meta分析

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氯己定全身洗浴对预防ICU患者导尿管相关性尿路感染的Meta分析

孙建华刘大为王小亭刘金榜罗红波刘佳涛

北京协和医院重症医学科

出版日期:2016-05-25 发布日期:2016-05-25

Chlorhexidine body bathing to prevent preventing catheter associated urinary tract infections in intensive care units: a Meta-analysis

Online:2016-05-25 Published:2016-05-25

摘要/Abstract

摘要： 目的：评价氯己定全身洗浴对ICU 患者导尿管相关性尿路感染的预防效果。方法：计算机检索Cochrane 图书馆、Pubmed、Ovid Medline、EMbase、中国生物医学文献服务系统（CBM）、维普数据库（VIP）、中国期刊全文数据库（CNKI) 以及万方数据库（Wan Fang Data) 中关于氯己定全身洗浴用于预防ICU 患者导尿管相关性尿路感染的随机对照试验、临床对照实验。2 名研究者独立检索、筛查文献、提取数据、评价纳入文献的方法学质量并交叉核对后，采用RevMan 5.3 软件进行Meta 分析、亚组分析。结果：共纳入8 篇文献，2篇随机对照试验和6 篇临床对照实验。Meta 分析结果显示：与肥皂水擦浴相比，氯己定全身洗浴可以降低ICU患者导尿管相关性尿路感染的发生率[RR=0.76，95%CI（0.60 ～ 0.95），P =0.02]，差异具有统计学意义。结论：氯己定全身洗浴可以降低ICU 患者导尿管相关性尿路感染的发生率，建议临床推广。

Abstract: Objective: To evaluate the impact of body bathing with chlorhexidine solution on preventing catheter associated urinary tract infections in ICU. Methods: Electronic searches of databases were performed to identify relevant randomized controlled trials (RCTs) and clinical control studies (CCTs). The databases used were Cochrane Library,PubMed, Medline/Ovid, EMbase, CBM, VIP, CNKI, and Wan Fang Data. Two reviewers independently screened potentially eligible articles, extracted data and assessed risk of bias. RevMan 5.3 software was used to perform Metaanalysis and sub-group analysis. Results:8 published studies were recruited for systematic review, which contained 2 RCTs and 6 CCTs. The results of Meta-analysis showed that, compared with non-medicated soap group, body bathing with chlorhexidine had significantly decreased the incidences of catheter associated urinary tract infection [RR=0.76, 95% CI(0.60~0.95), P=0.02]. Conclusions: Total body bathing with chlorhexidine is associated with decreased catheter associated urinary tract infection rate in ICU.

孙建华刘大为王小亭刘金榜罗红波刘佳涛. 氯己定全身洗浴对预防ICU患者导尿管相关性尿路感染的Meta分析[J]. , 2016, 16(5): 650-654.