Abstract: Objective: To investigate the depression level and the influencing factors among caregivers of adult leukemia patients, and to provide evidence for clinicians to implement individualized intervention. Method: Totally 207 adult leukemia patients and their primary caregivers were recruited by convenience sampling method in five tertiary grade A hospitals in Hangzhou and Ningbo, and were investigated using Center for Epidemiological Survey, Depression Scale (CES-D). Results: The depression level among caregivers of adult leukemia patients was high with the average CES-D score of (20.36±14.22). Totally 113 caregivers (54.59%) were depressive patients or might be depressed patients(CES-D score 16 points).The main influencing factors of caregiver depression scores were the patients' education background and the caregivers' education background, age, family monthly income, care time and having helpers or not.Conclusions: This study suggests that the depression among primary caregivers of adult leukemia patients is so serious that the medical staff should pay more attention to these population.