Abstract: Pressure ulcers has been a common problem faced by the global health care institutions, which seriously threat patients' life and health. Correct cognition and effective management of pressure ulcers was vitally important to prevention and treatment of pressure ulcers. This article focused on the interpretation of the main update content of 2014 Edition Prevention and Treatment of Pressure Ulcers: Clinical Practice Guideline formulated jointly by EPUAP (European Pressure Ulcer Advisory Panel), NPUAP (National Pressure Ulcer Advisory Panel) and PPPIA (Pan Pacific Pressure Injury Alliance), which included research and report of prevalence and incident, prevention, treatment of pressure ulcers, prevention and treatment of special populations, implementing guidelines. This article is to help nurses to get latest literature of pressure ulcers related topics, so as to enhance the pressure ulcers management level and efficiency and reduce the pain and burden of patients.