Abstract: Objective: To evaluate the effect of Maternal Sound Stimulation(MSS) on the progress and performance of oral feeding.Methods: Totally 62 premature infants were recruited and randomly divided into research group with 32 infants and control group with 30 infants. The infants in the control group received routine care, while the infants in the research group received MSS twice a day for seven days in addition to the routine care, We recorded the initiation time of oral feeding and the time of full oral feeding and observed the feeding performance in the two time points and calculated the transition time, feeding efficiency, sucking efficiency, etc., and recorded everyday's body weight,, the incidence of feeding intolerance and the discharge time. Results: The feeding efficiency and sucking efficiency at the initiation time of oral feeding, and the feeding efficiency at the time of full oral feeding in research group were significantly better than those of the control group (P<0.05), however there was no significant difference in the sucking efficiency between the two groups at the time of full oral feeding .The transitional time from the initiation of oral feeding to full oral feeding, the length of hospitalized stay, and the incidence of feeding intolerance in the research group were better than those of the control group(P<0.05). There was no significant difference in the weight gain between the two groups (P>0.05). Conclusion: MSS could effectively improve the progress and performance of oral feeding , and reduce the incidence of feeding intolerance among premature infants.