Abstract: Objective: This study aimed to develop a competency assessment indicator system for hemopurification nurses in China by using Delphi Technique. Methods: After a comprehensive literature review, theory analysis and semi-structured interview, the competency assessment indicator system for hemopurification nurses was developed by two rounds of questionnaire survey. Weight coefficients of the first and second level indicators were determined by combining Delphi technique and Analytic Hierarchy Process. Results: The competency assessment indicator system for hemopurification nurses composed of 4 first level indicators (professional knowledge, skills, abilities and psychological traits), 20 second level indicators and 48 third level indicators. The authoritative coefficient was 0.900; the coordination coefficients of the second round survey (0.554, 0.533, 0.579) were all better than those of the first round (0.436, 0.315, 0.318).Conclusions: The development of competency assessment indicator system for hemopurification nurses followed a robust research method. It could be applied in the human resource management of hemopurification nurses.