Abstract: Objective: To investigate the care burden level and influencing factors among the family caregivers of the disabled elderly. Methods: A total of 135 family caregivers from 2 tertiary level first class hospitals were investigated using the Zarit Burden Interview (ZBI), Social Support Ratings Scale (SSRS) and General Self-Efficacy Scale (GSES). Results: The total score of family caregivers' burden was (39.56±12.88). Regression analysis (R2=0.539, F=20.206, P<0.001) showed that the main influencing factors of caregivers burden including subjective support, depression or anxiety symptom, the total care time, objective support level and self-efficacy level of the caregivers, Barthel index score and the number of chronic diseases of the disabled elderly. Conclusion: The care burden among family caregivers of the disabled elderly was in a moderate level and was influenced by diverse care receiver and caregiver characteristics. The medical staff should comprehensive assess the disabled elderly and their family caregivers, to understand the status of the caregiver's burden and influencing factors, to take corresponding measures to reduce the burden of caregivers, and improve the quality of family care function and their life.