Abstract: Objective: To explore the practice of Family-Centered Care model on children's stoma nursing. Method: Nurses were trained by Family-Centered Care education and were divided into different groups to provide care for the patients with the doctors. Goals of family care were set and holistic nursing procedures and principles were established. Totally 52 children with stomas were cared using the Family-Centered Care model. Family members participated in the whole medical and nursing care process. Results: The capabilities of the 52 families were qualified. None of them returned to the hospital for treatment of complications during family care period. The results of the laboratory tests and examinations were normal and reached the criteria of the second surgeries. Conclusion: Family-Centered Care model on children's stoma nursing may increase the quality of life and sense of happiness of the children with stoma. It fits the health needs of Chinese families and the demand of current reform of the health system.