关键词: 造血干细胞移植；保护性隔离；孤独感；信度；效度

Abstract: Objective: To translate Perception of Protective Isolation (ISOLA) scale into Chinese and evaluate its reliability and validity among hematopoietic stem cell transplantation patients, and to provide a tool for assessing protective isolation in this population. Methods: The translation and cross-cultural adaptation of ISOLA scales were completed according to Brislin criteria. A convenient sample of 151 patients with hematopoietic stem cell transplantation in protective isolation was recruited from 6 haematology centers in Beijing and Hebei provinces between May to July, 2021. The psychometric properties of the scale were evaluated by item analysis, validity test and reliability analysis. Results: The Chinese version of ISOLA included 3 dimensions and 13 items. The S-CVI was 0.949 and the range of I-CVI was between 0.860 to 1.000. Cronbach's α of the total scale was 0.825, and Cronbach's α of the 3 dimensions were between 0.728 to 0.838, the split-half coefficient for the total scale was 0.827. Conclusion: The Chinese version of ISOLA scale has good reliability and validity, which can be used as an effective tool for assessing protective isolation of loneliness among hematopoietic stem cell transplantation patients.

Key words: hematopoietic stem cell transplantation; protective isolation; loneliness; reliability; validity