Abstract: Objective: To analyze the clinical application effect of early goal-directed mobilization protocols in patients after pancreatic tumor resection, in order to improve the effectiveness and initiative of early activity and promote postoperative recovery of patients. Methods: We randomly selected 35 patients who underwent pancreatic surgery at a tertiary grade A hospital in Shanghai from March to May 2023 as the control group, and 35 patients from June to August 2023 as the experimental group. The control group was treated with routine nursing measures after pancreatic tumor resection, and the experimental group applied the early goal-directed mobilization protocols in supervising the early activities of the patients. The effectiveness of the protocol was evaluated by comparing the time of first getting out of bed, flatus, defecation, oral drinking, urinary catheter removal and gastric tube removal between the two groups. The occurrence of postoperative complications and activity-related adverse events were compared between the two groups to evaluate the safety of the protocol. Results: There were statistically significant differences in the time of first getting out of bed, flatus, defecation and oral drinking between the two groups (P<0.05). There were no significant differences in urinary catheter removal time, gastric tube removal time and postoperative complications between the two groups (P>0.05). No exercise-related adverse events were observed in either group. Conclusion: Early goal-directed mobilization protocols is safe and effective in promoting early ambulation, early drink oral water and postoperative ventilation and defecation after surgery, no increased risk of postoperative bleeding, unplanned extubation and death.

Key words: pancreaticoduodenectomy; distal pancreatectomy; total pancreatectomy; early goal-directed mobilization; evidence-based practice; Enhanced Recovery After Surgery