Abstract: Objective: To develop MD Anderson Symptom Inventory-Acute Leukemia Module and assess its reliability and validity. Methods: A preliminary scale was developed through literature review, semi-structured interviews, Delphi expert consultation, and patient pre-surveys. A clinical investigation involving 235 adult patients with Acute Leukemia was conducted to assess its reliability and validity. Results: MD Anderson Symptom Inventory-Acute Leukemia Module consists of 25 items, including 19 symptom items and 6 items assessing the interference of symptoms with daily life. The content validity results indicate that both the I-CVI and S-CVI are greater than 0.8. The results of confirmatory factor analysis showed that the revised model suitability indexes were χ2/df=2.230, RMSEA=0.072, GFI=0.976, CFI=0.955, IFI=0.956, NFI=0.923, TLI=0.915. The Cronbach's α coefficient for the total MD Anderson Symptom Inventory-Acute Leukemia Module is 0.941, while the Cronbach's α coefficient for the Acute Leukemia Module is 0.707. Conclusion: MD Anderson Symptom Inventory-Acute Leukemia Module developed in this study has demonstrated good reliability, and validity. It is an accurate and objective tool for assessing symptoms of Acute Leukemia patients.

Key words: Acute Leukemia; MD Anderson Symptom Inventory; symptom; assessment tools; reliability; validity