Abstract: Objective: To construct a medication safety management plan for tertiary hospitals based on Team Resource Management (TRM) and evaluate its application effectiveness, and to provide a reference for improving the medication safety of patients. Methods: We constructed a tertiary hospital medication safety management plan from 4 modules of TRM: leadership coordination, condition monitoring, mutual assistance and cooperation, and effective communication, and developed specific implementation strategies as well. Key process indicators of medication, nurse medication safety ability, and safety attitude were compared before and after the implementation of plan. Results: After the implementation of plan, the number of medication near error events increased, drug configuration execution rate within 2 hours, pre-medication double check matching rate, and intravenous drug infusion velocity recording compliance rate all improved (P<0.05). The scores of nurse medication safety ability and safety attitude were higher than that before the implementation of plan (P<0.05). Conclusion: The medication safety management plan based on TRM can enhance the safety medication ability of nurses, standardize the medication execution process, and enhance the safety culture awareness of medical staff teams.

Key words: Team Resource Management; hospital; medication safety; administration