Abstract: Objective: To evaluate the effectiveness of Pediatric Parenteral Nutrition Intravenous Administration Evidence-adaptive Clinical Decision Support System (PN-CDSS) on nurses' compliance with safe Parenteral Nutrition (PN) administration behaviors. Methods: From November 2021 to August 2022, a step-wedge cluster randomized controlled trial of the implementation plan of PN-CDSS was conducted in five wards of a tertiary grade A pediatric specialty hospital in Shanghai. Nurses in these departments were intervened, with each ward being included in the step as per the randomization results. The compliance of nurse medication safety behaviors before and after implementation were compared. Results: After the implementation of PN-CDSS, the rate of pre-administration assessment for PN increased from 0 to 100.0%. And significant improvements were observed in the double-checking rate for PN and the execution rate of PN infusion via a Central Venous Catheter (P<0.05). However, there was no significant change in the rate of hourly assessment for PN (P>0.05). Conclusion: The PN-CDSS aid pediatric nurses in conducting pre-administration assessments, performing double checks and choosing right catheter, thereby enhancing the nursing medication administration safety behaviors.

Key words: Clinical Decision Support System; Parenteral Nutrition; children; medication administration