Abstract: Objective: To evaluate the effects of Cryo/Cuff on blood loss and safety for patients after bilateral Total Knee Arthroplasty (TKA). Methods: Totally 100 patients were randomly divided into the experimental group and the control group. In the experimental group, Cryo/Cuff was used immediately after patients returned from the operating room for 2h. In the control group, sham Cryo/Cuff was used at the same time. Blood loss and Deep Vein Thrombosis (DVT) were compared between the two groups. Frostbite was calculated in the experimental group. Results: Wound drainage, total body blood loss, Hemoglobin decrease in the experimental group were less than the control group (P<0.05). There was no significant difference in blood transfusion rate and DVT rate between the two groups (P>0.05). There was no frostbite case in the experimental group. Conclusion: As an effective and safe treatment, Cryo/Cuff can effectively reduce blood loss for bilateral TKA patients, which is conducive to the early rehabilitation of patients.

Key words: Cryo/Cuff; arthroplasty, replacement, knee; blood loss