Abstract: Objective: To test the reliability and validity of the Chinese version of Care Dependency Scale (CDS) in cancer patients. Methods: Three hundred and twenty-nine cancer patients were selected by convenience sampling. The construct validity was tested using an exploratory factor analysis, the reliaility was estimated using Cronbach’s α coefficient and rest-retest reliability. Results: Factor analysis identified two factors, and the cumulative variance contribution rate was 69.8%. The Chinese version of CDS and ADL were significantly correlated (r=0.91, P<0.001). The content validity index was 0.833. The Cronbach’s α coefficient (0.944) and test-retest reliability (0.667) was acceptable. Conclusion: The Chinese version of CDS has high reliability and validity, which may be used for monitoring the level of CDS in Chinese cancer patients.