Abstract: The 21st century is the era of globalization, competitiveness, innovation, and information. Each country faces different conditions, such as war, disaster, climate changes, diseases outbreak, resource shortage, economic crisis or difficulties. The above factors affect the global health and wellbeing; in the meanwhile threaten the humanity and human right. Nurses are the core of health care system to take the responsibilities on health promotion, illness prevention and treatment. They always stand the first line. If nurses can stand up and speak up, to lead the voice by presenting the knowledge, evidence and influence to protect minorities, or make efforts on policy making and problem solving. They will make great contribution to the society and benefited to achieve the SDGs.