Abstract: Objective: To explore the current situation and influence factors of PICC care in children with cancer during intermittent chemotherapy. Methods: The 114 children with cancer and their parents were investigated with self designed questionnaire, which included items of knowledge, attitude and behavior about PICC maintenance. Results: The total score of the questionnaire was (79.83±10.18). The score of the knowledge, attitude and behaviour of PICC maintenance was (29.61±5.87), (15.60±2.32) and (34.63±4.66) respectively. The age of children, parents education level and family income had influence on the PICC maintenance level. Conclusion: Nurses can provide education on PICC maintenance based on the children's age and their parents' background to reduce the side effects of PICC during intermittent chemotherapy, and improve the quality of life of the children with cancer.