Abstract: Objective: To apply the evidence on non-pharmacological prevention and management of Cancer-Related Fatigue (CRF) in adult cancer patients into clinical practice using the Stetler Model of Research Utilization and assess its effectiveness, in order to promote the translation of evidence into clinical practice. Methods: Relevant literature was systematically retrieved. From April to September 2024, five tumor-related departments in a tertiary grade A hospital in Guangdong were selected using a stepped-wedge cluster randomized sampling method. Differences in the implementation rate of CRF non-pharmacological management measures and the incidence of CRF before and after evidence-based practice were compared. Results: Through evidence-based practice, the incidence of CRF decreased from 51.4% to 49.1%. The proportion of CRF patients receiving drug treatment decreased from 68.4% to 34.8%. The cross-incidence rate of other treatment-related adverse reactions and the implementation rate of non-pharmacological management measures were superior to those of patients in the pre-evidence-based practice period (P<0.05). Conclusion: Applying the Stetler Model to non-pharmacological prevention and management of CRF in cancer patients promotes nurses' standardized implementation of CRF measures, reduces CRF incidence, and provides a basis for clinical use of non-pharmacological management programs to improve CRF.

Key words: cancer patient; Cancer-Related Fatigue; non-drug prevention and management; evidence-based practice