Abstract: Objective: To explore the application effect of Lean Six Sigma based full chain closed-loop nursing management in elderly patients with chronic diseases, and provide reference for optimizing service processes and improving medical experience in clinical nursing management practice. Methods: Using convenience sampling method, select a tertiary Grade A comprehensive hospital in Qingdao as of 273 elderly patients admitted to the hospital from March to June 2023 were selected as the control group, and 273 elderly patients admitted from July to October 2023 were selected as the observation group. The observation group was treated with a full chain closed-loop nursing management process based on Lean Six Sigma. Compare the differences between two groups of patients in terms of the time required for handling entry and exit procedures, evaluation of nursing service experience, and the quality of humanistic care provided by nurses. Results: The time required for patients in the observation group to complete admission and discharge procedures was (5.51±1.76) and (2.36±0.55) minutes, respectively, which was shorter than that of the control group (59.03±4.23) and (59.69±3.56) min, and the nursing service experience evaluation and nurse humanistic care quality were better than the control group, with statistically significant differences (P<0.001), nursing service experience evaluation, and nurse humanistic care quality compared to the control group, with statistical significance (P<0.001). Conclusion: Applying the full chain closed-loop nursing management based on Lean Six Sigma to elderly patients with chronic diseases can effectively shorten the time required for patients to handle entry and exit procedures, improve patient nursing service experience and nurse humanistic care quality, and provide reference for further clinical promotion and application.

Key words: chronic disease; Lean Six Sigma; closed-loop management; nursing management