Abstract: Objective: To investigate the Fear of Cancer Recurrence (FCR) in patients with hematological malignancy after Hematopoietic Stem Cell Transplantation (HSCT) and their spouses, and construct the Actor-Partner Interdependence Mode extended to Mediation of intimate relationship on dyadic coping and FCR, providing theoretical guidance for clinical staff to develop scientifically effective dyadic intervention measures. Methods: By using convenient sampling method, from May to December 2021, a total of 249 hospitalized and reexamined patients after HSCT and their spouses were investigated with general information questionnaire, Fear of Progression Questionnaire-Short Form, Fear of Progression Questionnaire-Short Form/Partner, Dyadic Coping Inventory, the Lock-Wallace Marriage Relationship Adjustment Scale. Results: In terms of actor mediating effect, patients' positive dyadic coping and negative dyadic coping could affect their FCR through the intimate relationship on themselves' and their spouses', the spouse's negative dyadic coping could only affect their FCR through their own intimate relationship; in terms of partner mediating effect, patients' positive dyadic coping and negative dyadic coping could affect their spouse's FCR through their spouse's intimate relationship, spouse's negative dyadic coping could affect the patient's FCR through the intimate relationship on themselves' and their spouses'. Conclusion: The dyadic coping of patients after HSCT and their spouse can affect their own or their spouse's FCR through the intimate relationship between the husband and wife, which suggest that medical staff should carry out dyadic intervention on the patient and spouse as a whole, improving the intimate relationship and reducing the FCR.

Key words: Hematopoietic Stem Cell Transplantation; dyadic coping; intimate relationship; Fear of Cancer Recurrence; Actor-Partner Interdependence Mode extended to Mediation