Abstract: Objective: To explore the influence of Computerized Cognitive Training on depression and anxiety among cognitively healthy adults and elderly in order to provide evidence for clinical practice. Methods: Cochrane Library, PubMed MEDLINE, Web of Science, Elsevier, EBSCO ASP&BSP, Lippincontt Williams& Wilkins, EMBASE, CBM, CNKI, Wanfang Data and VIP were searched to collect randomized controlled trials (RCTs). The quality of RCTs was critically appraised and data were extracted by 2 reviewers independently. Meta-analysis was conducted for eligible RCTs. Results: Seven RCTs with417 subjects were included. Through Meta-analysis significant differences were observed in depression [SMD=?-0.43, 95% CI (-0.63, -0.23), P<0.05] and anxiety [SMD=?-0.73, 95% CI (-1.46,-0.01), P=0.05] between the Computerized Cognitive Training group and the control group. Conclusion: Computerized Cognitive Training has an advantage in reducing the depression and anxiety among cognitively healthy adults and elderly. Because of the difference among indicators, the settings of the control group, and frequency of interventions, studies with larger sample size and higher quality are needed in future.

Key words: Computerized Cognitive Training; depression; anxiety; adults; elderly; Meta-analysis