Abstract: Objective: To analyze the effect of Supportive Self-Management Mode on rehabilitation administration and management of discharged patients with depression. Methods: Patients with depression discharging from mood disorders ward were recruited during August of 2015 to October of 2016. Participants were randomly divided into the observation group (n=34) and the control group (n=33) using random number method. Both groups were given typical antidepressant treatment, conventional discharge nursing and health education. Moreover, the observation group was also given supportive self-management interventions according to Supportive Self-Management Mode. Hamilton Depression Scale (HAMD), Self-Efficacy Scale (SES) and WHO Quality of Life-Abbreviated Version (WHOQOL-BREF) were used to assess patients before their discharge, 2 months, 4 months and 6 months after their discharge separately. Results: Patients of the observation group scored significantly lower than the control group using HAMD. Patients of the observation group got significantly higher scores than the control group as to self-efficacy level, psychological dimension and physical dimension using WHOQOL-BREF. Conclusion: Supportive Self-Management Mode could help control symptoms of patients with depression and improve their self-efficacy and quality of life.