Abstract: Objective: To explore the effects of MDT care mode on quality of life of senile dementia patients. Methods: Using convenience sampling method, a total of 74 senile dementia patients from a pension institution were recruited from July 2015 to March 2016 and MDT comprehensive intervention was used. The scores of Activities of Daily Living Questionnaire (ADLQ) and the Quality of Life-Alzheimer Disease (QOL-AD) were compared at baseline, intervention for 3 and 6 months. Results: Scores of ADLQ subscales at 6 months later were lower than baseline and there were significantly lower in the self-care, household care, employment and recreation, communication (P<0.05). Both QOL-AD (caregivers rated) and QOL-AD (patients rated) scores were higher than baseline (P<0.05). Conclusion: MDT care mode can effectively reduce the dependence of daily life activities on senile dementia patients and improve the quality of life of them. Optimizing the MDT care mode and improving the overall quality of care need research in-depth in the further.