Abstract: We designed and applied intelligent infant anti-theft system, connected it with HIS and mobile nursing information system in real-time, and realized the real-time data exchange. Nurses could accomplish the operation of maternal-infant pairs, alarming, and temporary out by the intelligent interactive terminal. The intelligent infant anti-theft system could timely and efficiently show the infant's location information, achieve a full range of regional monitoring, prevent theft of infant in hospitals, and ensure infant security.